D I V I S I O N  O F  N E U R O P A T H O L O G Y

U n i v e r s i t y  o f  P i t t s b u r g h  S c h o o l  o f  M e d i c i n e

D e p a r t m e n t  o f  P a t h o l o g y


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This conference will be held weekly on Thursday at 9 AM in the NP Sign-Out Room (A722 Scaife Hall). Faculty and fellows will have the option to present current surgical cases or a paper of interest.  If presenting a paper one week ahead of their assigned conference, faculty and fellows should email Karen Weber the pdf of the article they will present so she can post it in time for everyone to read. The conference will be announced in the weekly Division notice and papers will be posted here on the Division web site. Conference participants should read the paper BEFORE coming to the session. Article presentations are limited to 20 minutes followed by up to 10 minutes of discussion. Obviously the whole article cannot be presented in that time so the presenter must be efficient and selective in choosing what to show.

The conference is open to faculty, fellows, residents and students. Please email Karen if you would like to be included in the distribution list.

2014 Sessions

Updated: 10/9/14

January 8, 2014 Lananh Nguyen BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors. Prabowo AS et al. Brain Pathol 2014;24:52-66.
February 12, 2014 Geoff Murdoch Nodule formation and desmoplasia in medulloblastoma--Defining the nodular/desmoplastic variant and its biological behavior. McManamy CS, et al. DOI 10.1111/j.1750-3639.2007.00058.x
February 26, 2014 Leo Arvanitis TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Killela PJ et al. PNAS 2013;110(15):6021-6026.
April 2, 2013 Clayton Wiley

B-Amyloid precursor protein staining of the brain in sudden infant and early childhood death. Jensen LL, et al. doi: 10.1111/nan.12109.

Link to article exploring legal aspects of Shaken Baby Syndrome

May 7, 2014 Lananh Nguyen LOX-1 Is a novel therapeutic target in neonatal hypoxic-ischemic encephalopathy. Akamatsu T. The American Journal of Pathology
June 4, 2014 Julia Kofler Current Vaccine Trials in Glioblastoma: A Review. Xu LW et al. JImmunol Res Volume 2014, Artice ID 796856, 10 pages.
June 11, 2014 CANCELED  
June 18, 2014 Charleen Chu / Avi Ettyreddy (Med Student)  
June 25, 2014 Clayton Wiley What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Fjell AM, et al. Progress in Neurobiology xxx (2014) xxx-xxx.
July 2, 2014 Ronald Hamilton Diagnostic yield of stereotactic needle-biopsies of sub-cubic centimeter intracranial lesions. Waters JD. Surgical Neurology International.
July 10, 2014 Scott Kulich  
July 17, 2014 Clayton Wiley Examination of the clinicopathologic continuum of Alzheimer Disease in the autopsy cohort of the National Alzheimer Coordinating Center. Serrano-Pozo A, et al. J Neuropath Exp Neurol 2013;72(12):1182-1192.
July 24, 2014 Clayton Wiley CNS Lymphoma: A Practical Diagnostic Approach. Giannini C, et al. J Neuropathol Exp Neurol. 2014;73(6):478-494
July 31, 2014 Charleen Chu Case Presentation
August 7, 2014 Geoff Murdoch Paper Presentation
August 14, 2014 Ronald Hamilton CANCELED
August 21, 2014 Clayton Wiley The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimers Disease? Winkler EA, et al. Brain Pathology 2014;24:371-386
August 28, 2014 Julia Kofler CANCELED
September 4, 2014 Julia Kofler CANCELED
September 11, 2014 Charleen Chu CANCELED
September 18, 2014 Geoff Murdoch CANCELED
September 25, 2014 Ronald Hamilton BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinamatous craniopharyngioma. Larkin SJ, et al. Acta Neuropathol 2014;127:927-929
October 2, 2014 Scott Kulich  

2013 Sessions

Updated: 10/8/2013

January 17, 2013 Ronald Hamilton Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas. Gonzalez-Aguilar A, et al. Clin Cancer Res 2012;18(19):5203-11.
February 7, 2013 Ken Clark PDGFRA Gain in Low-Grade Diffuse Gliomas. Motomura K, et al. J Neuropathol Exp Neurol 2013;72(1):61-66.
March 7, 2013 Kate McFadden BRAF Duplications and MAPK Pathway Activation are Frequent in Gliomas of the Optic Nerve Proper. Rodriguez FJ, et al. J Neuropathol Exp Neurol 2012;71(9):789-794.
April 4, 2013 Lananh Nguyen Longitudinal expression analysis of av integrins in human gliomas reveals upregulation of integrin avB3 as a negative prognostic factor. Schittenhelm J, et al. J Neuropathol Exp Neurol 2013;72(3):194-210.
May 2, 2013 Julia Kofler Evaluation of Histone 3 Lysine 27 Trimethylation
(H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas
. Venneti S, et al. Brain Pathol ISSN 1015-6305.
June 13, 2013 Leonidas Arvanitis An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells. Rohle D, et al. Science 2013;340:626-630.
July 11, 2013 Clayton Wiley What do we know about IDH1/2 mutations so far, and how do we use it? Horbinski C. Acta Neuropathol 2013;125:621-636.
October 9, 2013 Geoff Murdoch ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis. Wiestler B, et al. Acta Neuropathol 2013;126:443-451.
September 4, 2013 Lananh Nguyen Consensus Recommendations on Pathologic Changes in the Hippocampus: A Postmortem Multicenter Inter-Rater Study. Rauramaa T, et al. J Neuropathol Exp Neurol 2013;72(6):452-461.
November 6, 2013 Leonidas Arvanitis Paper. Kleinschmidt-DeMasters BK, et al. Am J Surg Pathol 2013;37(5):685-698.
December 11, 2013 Ronald Hamilton

Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? Albert HB, et al Eur Spine J 2013;22:690-696.

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Albert HB, et al. Eur Spine 2013;22:697-707.