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Stephanie Bissel, PhD

Research Assistant Professor, Department of Pathology

PhD, University of Pittsburgh 2005

 

Office Location
Contact Information

Neuropathology Division
University of Pittsburgh

Room S758 Scaife Hall

200 Lothrop Street

Pittsburgh, PA 15213

Office Telephone: 412-624-5452

Office Fax: 412-624-5264

Email: sjb75@pitt.edu

Research Interests:

My research concentrates on the involvement of immune responses in the pathogenesis of neurodegenerative diseases and in particular on viral and age-induced nervous system disease.  During viral infection, neuronal damage can be mediated by direct infection leading to neuronal death or impairment.  Although immune responses can promote clearance or suppression of viral replication, these responses are thought to mediate secondary neuronal damage.  Using two models of CNS viral infection, we can examine viral-induced neurodegeneration during acute and chronic infection of the CNS.  For chronic viral infection, we have focused on dissecting effects of prolonged immune activation on CNS cells using models of lentiviral encephalitis.  Since lentiviruses do not directly infect neurons, neuronal damage is thought to be immune-mediated.  We have recently focused on acute CNS viral infections using models of influenza encephalitis - a virus that infects neurons.  This model will be used to examine whether acute viral infection of neurons leads to prolonged low-grade inflammation and subsequent neuronal damage.

A second area of interest involves regulation of immune cell activation in the CNS.   Several extracellular molecules present on microglia, neurons, and astrocytes are thought to dampen or inhibit microglia or trafficking macrophages and T lymphocytes.  We are developing models to study these interactions in normal and diseased tissues.

View Dr. Bissel’s publications on PubMed

View Dr. Bissel’s Biosketch