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U n i v e r s i t y  o f  P i t t s b u r g h  S c h o o l  o f  M e d i c i n e

D e p a r t m e n t  o f  P a t h o l o g y


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Scott M. Kulich, MD, PhD

Associate Professor of Pathology

MD, Medical College of Wisconsin 1996

Office Location
Contact Information

UPMC Presbyterian Hospital

Division of Neuropathology

Room A724.1 Scaife Hall

200 Lothrop Street

Pittsburgh, PA 15213

Office Telephone: 412-624-6610

Office Fax: 412-624-5610

Email: kulichsm@upmc.edu

Research Interests:

My laboratory is interested in the study of the interaction between oxidative neurotoxins and intracellular signal transduction cascades in the context of neurologic diseases. In particular, a major focus of the lab is understanding the molecular mechanisms involved in 6-hydroxydopamine-mediated neurotoxicity as a model for Parkinson's disease by studying the influence of this Parkinsonian neurotoxin on mitogen activated protein kinase signaling cascades both in cell culture and animal model systems.

Selected Publications:

RK Dagda, SJ Cherra III, SM Kulich, A. Tandon, D. Park, CT Chu (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem 280:13843-55 PMID: 19279012

RK Dagda, JH Zhu, SM Kulich, CT Chu (2008) Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress induced by 6-hydroxydopamine. Autophagy. 4:770-82. PMID: 18594198.

SM Kulich, C Horbinski, M Patel, CT Chu (2007) 6-hydroxydopamine induces mitochondrial ERK activation. Free Radic. Biol. Med. 43:372-383. PMID: 17602953

CT Chu, DJ Levinthal, SM Kulich, EM Chalovich, and DB DeFranco (2004) Oxidative neuronal injury: The dark side of ERK 1/2. Eur J Biochem, in press

SM Kulich & CT Chu (2003) Role of reactive oxygen species in ERK phosphorylation and 6-hydroxydopamine cytotoxicity. J. Biosci 28:83-89.

EJ Kwak, DC Strollo, SM Kulich, and S Kusne (2003) Cavitary pneumonia due to Rhodococcus equi in a heart transplant recipient. Transpl. Infect. Dis 5:43-46.

JH Zhu, SM Kulich, TD Oury & CT Chu (2002) Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am. J. Pathol. 161: 2087-2098.

SM Kulich and CT Chu (2001) Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: Implications for Parkinson’s disease. J. Neurochem. 77: 1058-1066.

AM Scarrow, EI Levy, SM Kulich, CT Chu, and PC Gerszten (2001) Epidermoid cyst of the thoracic spine: case history. Clin. Neurol. & Neurosurg. 103:220-222.