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Scott M. Kulich, MD, PhD

Associate Professor, Department of Pathology

MD, Medical College of Wisconsin 1996

Office Location
Contact Information

VA Healthcare System

University Drive C

2NE120

Pittsburgh, PA 15240

Office Telephone: 412-360-6548

Office Fax: 412-360-6872

Email: kulichsm@upmc.edu

Research Interests:


My laboratory is interested in the study of the interaction between oxidative neurotoxins and intracellular signal transduction cascades in the context of neurologic diseases. In particular, a major focus of the lab is understanding the molecular mechanisms involved in 6-hydroxydopamine-mediated neurotoxicity as a model for Parkinson's disease by studying the influence of this Parkinsonian neurotoxin on mitogen activated protein kinase signaling cascades both in cell culture and animal model systems.

Selected Publications:

RK Dagda, SJ Cherra III, SM Kulich, A. Tandon, D. Park, CT Chu (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem 280:13843-55 PMID: 19279012

RK Dagda, JH Zhu, SM Kulich, CT Chu (2008) Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress induced by 6-hydroxydopamine. Autophagy. 4:770-82. PMID: 18594198.

SM Kulich, C Horbinski, M Patel, CT Chu (2007) 6-hydroxydopamine induces mitochondrial ERK activation. Free Radic. Biol. Med. 43:372-383. PMID: 17602953

CT Chu, DJ Levinthal, SM Kulich, EM Chalovich, and DB DeFranco (2004) Oxidative neuronal injury: The dark side of ERK 1/2. Eur J Biochem, in press

SM Kulich & CT Chu (2003) Role of reactive oxygen species in ERK phosphorylation and 6-hydroxydopamine cytotoxicity. J. Biosci 28:83-89.

EJ Kwak, DC Strollo, SM Kulich, and S Kusne (2003) Cavitary pneumonia due to Rhodococcus equi in a heart transplant recipient. Transpl. Infect. Dis 5:43-46.

JH Zhu, SM Kulich, TD Oury & CT Chu (2002) Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am. J. Pathol. 161: 2087-2098.

SM Kulich and CT Chu (2001) Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: Implications for Parkinson’s disease. J. Neurochem. 77: 1058-1066.

AM Scarrow, EI Levy, SM Kulich, CT Chu, and PC Gerszten (2001) Epidermoid cyst of the thoracic spine: case history. Clin. Neurol. & Neurosurg. 103:220-222.