Office Location:

Room A551 PUH

Office Telephone: (412) 647-1706
Office Fax: (412) 647-5602
Email: lacomisd@upmc.edu

Research Interests:

Dr. Lacomis specializes in neuromuscular diseases and neuromuscular pathology. His research interests include (1) the histopathologic features of critical illness myopathy, especially with regard to the loss of myosin thick filaments; (2) histopathologic and electrophysiologic correlation in inflammatory myopathies and peripheral nervous system vasculitis; (3) clinical trials in amyotrohic lateral sclerosis; and (4) toxic and small fiber neuropathies.

Selected Publications:

Campellone JV, Lacomis D, Giuliani MJ, Oddis CV. Percutaneous needle biopsy in the evaluation of patients with with suspected inflammatory myopathy. Arthritis Rheum 1997; 40:1886-1891.

Lacomis D, Chad DA, Smith TW. Myopathy in the elderly: Evaluation of the histopathological spectrum and the accuracy of the clinical diagnosis. Neurology 1993; 43:825-828.

Lacomis D, Giuliani M, Van Cott A, Kramer DJ. Acute myopathy of intensive care. Clinical, EMG, and pathologic aspects. Ann Neurol 1996; 40:645-654.

Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ. Acute myopathy after liver transplantation. Neurology 1998; 50:46-53.

Lacomis D, Petrella JT, Giuliani MJ. Causes of neuromuscular weakness in the intensive care unit. A study of 92 patients. Muscle Nerve 1998; 21:986-901.

Lacomis D, Oddis CV. Myositis-specific and associated autoantibodies: A review from the clinical perspective. J Clin Neuromusc Dis 2000;2:34-40.

Pulipaka U, Lacomis D, Omalu B. Amiodarone-induced neuromyopathy: Three cases and review of literature. J Clin Neuromusc Dis 2002 In press.

Lacomis D. Small fiber neuropathy. Muscle Nerve 2002;26:173-188.

Kao AH, Lacomis D, Lucas M, Fertig N, Oddis CV. Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arth Rheum 2004;50:209-215.

Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli L, Newhall K, Cudkowicz ME, Brown Jr RH, Bowser R. Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. J Neurochem 2005;95:1461-1471.

Zivkovic SA, Asherman D, Lacomis D. Vasculitic neuropathy - electrodiagnostic findings and association with malignancies. Acta Neurol Scand, 2007;115:432-436.

Lacomis D, Zivkovic SA. Approach to vasculitic neuropathies. J. Clin Neuromusc Dis, 2007;9:265-276.

Ranganathan S, Georgina CBN, Henry S, Lutka F, Sathanoori R, Lacomis D, Bowser R. Comparative proteomic profiling of cerebrospinal fluid between living and postmortem ALS and control subjects. Amyotrophic Lateral Sclerosis, 2007;8:373-379.

Wang H, Larrieviere KS, Keller KE, Ware KA, Burns TM, Conaway MA, Lacomis D, Pattee GL, Phillips LH, Solenski NJ, Zivkovic SA, Bennett JP. R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial Phase II Studies in ALS. Amyotrophic Lateral Sclerosis, in press.